Webinar: Super-resolution infrared imaging of polymorphic amyloid aggregates directly in neurons

 

Groot-Ammers | March 23rd, 2020

Coming Thursday, March 26th,  11:00 AM – 12:00 PM CET, Dr. Oxana Klementieva (Assistant Professor in Neurobiology, Lund University and Dr. Mustafa Kansiz (Director of Product Management, Photothermal Spectroscopy Corp.) will host the webinar titled ‘Amyloid aggregates in neurons – Life Science applications with submicron simultaneous IR+Raman microscopy’.

Dr. Oxana Klementieva and co-workers identifying amyloid-beta aggregates directly in neurons (neurites an dendritic spines) at the subcellular (submicron) level using Optical Photothermal Infrared (O-PTIR) imaging (mIRage submicron Infrared Microscope).

They provided a glimpse of what might occur at earlier stages of Alzheimer’s Disease pathology showing that in neurons, amyloid aggregates can have structural polymorphism, which may trigger various mechanisms of Alzheimer’s disease progression.

The webinar will be recorded for later on-demand viewing with opportunities to ask questions during and after the webinar.

Biography:

Oxana Klementieva is Assistant Professor in Neurobiology and head of the Medical Microspectroscopy laboratory in the Department of Expserimental Medical Science, Faculty of Medicine, Lund University in Lund, Sweden. She is also a leader of Amyloid Group at Lund Institute of Advanced Neutron and x-Ray Science, Sweden. Her research the group focuses on Alzheimer’s and Parkinson’s disorders. Her research has focused on nonlinear polymers as anti-amyloid drug candidates for the treatment of Alzheimer’s disease. Her publication Klementieva et al., 2013, provided the first evidence that certain types of nonlinear polymers could be used to protect memory in Alzheimer’s disease mouse model. More recently, she become focused on native Abeta in the brain (Klementieva O et al., 2017) and development of ultraconservative methods for imaging of amyloid structures in neurons and brain tissue (Klementieva O et al., 2020).